Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.56 (overall 0.34) | 0.56 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 40 | 0.85 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 0957
Sealed predictions
- CCSER1 in dopamine neurons, braak-0.03 (p 0.946) → +0.75 (p 0.021)receipt 0964
Swarm cases
receipt 0964: CCSER1 in dopamine neurons, braak
- power
- full sample +0.48 (p 0.044, n 18), 95% CI +0.02 to +0.77. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.46 (p 0.057, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.51 (p 0.030, n 18). not the mix.
- skeptic
- leave-one-out range +0.42 to +0.66, sign flips 0; without severely affected donors +0.48 (p 0.044, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CCSER1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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