Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

CCN3

cellular communication network factor 3

translation score 0.37, read 2026-10-22; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.04 from other evidence0.00
cell type
Human Protein Atlas
expressed broadly, no clear home in brain cells0.40
chemistry
Open Targets
reachable by antibody0.36
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
2 Parkinson's papers of 4490.85
pathways
Reactome
in no curated pathway0.00

No case: the score is under the bar. Receipt 6189

Sealed predictions

  1. CCN3 in dopamine neurons, braakn/a → n/areceipt 6198

Swarm cases

receipt 6198: CCN3 in dopamine neurons, braak

cell type
CCN3 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CCN3 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

loading the receipts