Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.05 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (nk-cells) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 4 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 15 Parkinson's papers of 14,090 | 0.64 |
| pathways Reactome | 3 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 4912
Sealed predictions
- CCL4 in dopamine neurons, braak+0.00 (p 1.000) → -0.14 (p 0.722)receipt 4919
Swarm cases
receipt 4919: CCL4 in dopamine neurons, braak
- power
- full sample -0.07 (p 0.794, n 18), 95% CI -0.52 to +0.41. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.07 (p 0.794, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.05 (p 0.834, n 18). could be the mix.
- skeptic
- leave-one-out range -0.20 to +0.03, sign flips 4; without severely affected donors -0.07 (p 0.794, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CCL4 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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