Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.52 (overall 0.33) | 0.52 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 18 Parkinson's papers of 33 | 0.61 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 1042
Sealed predictions
- CCDC62 in dopamine neurons, braak-0.19 (p 0.618) → +0.37 (p 0.329)receipt 1049
Swarm cases
receipt 1049: CCDC62 in dopamine neurons, braak
- power
- full sample +0.11 (p 0.664, n 18), 95% CI -0.38 to +0.55. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.08 (p 0.761, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.08 (p 0.761, n 18). could be the mix.
- skeptic
- leave-one-out range -0.00 to +0.21, sign flips 1; without severely affected donors +0.11 (p 0.664, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CCDC62 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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