Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (distal convoluted tubule cells) | 0.10 |
| chemistry Open Targets | compounds already reach it: etelcalcetide, asp7991, etelcalcetide hydrochloride +4 | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 5 Parkinson's papers of 2,630 | 0.76 |
| pathways Reactome | 3 pathways; mostly dopamine synapse | 1.00 |
No case: the score is under the bar. Receipt 8761
Sealed predictions
- CASR in dopamine neurons, braak+0.27 (p 0.487) → -0.13 (p 0.733)receipt 8767
Swarm cases
receipt 8767: CASR in dopamine neurons, braak
- power
- full sample +0.04 (p 0.861, n 18), 95% CI -0.43 to +0.50. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.08 (p 0.767, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.16 (p 0.526, n 18). could be the mix.
- skeptic
- leave-one-out range -0.05 to +0.17, sign flips 6; without severely affected donors +0.04 (p 0.861, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CASR in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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