Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

CARS1

cysteinyl-tRNA synthetase 1

translation score 0.47, read 2026-10-25; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.01 from other evidence0.00
cell type
Human Protein Atlas
expressed broadly, no clear home in brain cells0.40
chemistry
Open Targets
hard to drug0.24
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
no papers tie it to Parkinson's yet1.00
pathways
Reactome
2 pathways; mostly growth signalling0.60

No case: the score is under the bar. Receipt 10207

Sealed predictions

  1. CARS1 in dopamine neurons, braakn/a → n/areceipt 10214

Swarm cases

receipt 10214: CARS1 in dopamine neurons, braak

cell type
CARS1 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CARS1 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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