Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

CAMK2N1

calcium/calmodulin dependent protein kinase II inhibitor 1

translation score 0.38, read 2026-10-17; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.29 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including oligodendrocytes; strongest in epididymal clear cells0.75
chemistry
Open Targets		hard to drug0.00
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		2 Parkinson's papers of 560.85
pathways
Reactome		in no curated pathway0.00

No case: the score is under the bar. Receipt 1327

Sealed predictions

  1. CAMK2N1 in oligodendrocytes, braak+0.30 (p 0.428) → +0.12 (p 0.756)receipt 1333
  2. CAMK2N1 in dopamine neurons, braak+0.00 (p 1.000) → +0.34 (p 0.378)receipt 1334

Swarm cases

receipt 1334: CAMK2N1 in dopamine neurons, braak

power
full sample +0.16 (p 0.532, n 18), 95% CI -0.33 to +0.58. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.13 (p 0.597, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.28 (p 0.261, n 18). could be the mix.
skeptic
leave-one-out range +0.05 to +0.29, sign flips 0; without severely affected donors +0.16 (p 0.532, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CAMK2N1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 1333: CAMK2N1 in oligodendrocytes, braak

power
full sample +0.19 (p 0.455, n 18), 95% CI -0.31 to +0.60. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.19 (p 0.455, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.27 (p 0.281, n 18). could be the mix.
skeptic
leave-one-out range +0.09 to +0.33, sign flips 0; without severely affected donors +0.19 (p 0.455, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CAMK2N1 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

loading the receipts