Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

CALML4

calmodulin like 4

translation score 0.41, read 2026-10-27; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.01 from other evidence0.00
cell type
Human Protein Atlas
cell type enhanced, including microglia; strongest in colonocytes0.75
chemistry
Open Targets
hard to drug0.00
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
no papers tie it to Parkinson's yet1.00
pathways
Reactome
in no curated pathway0.00

No case: the score is under the bar. Receipt 12144

Sealed predictions

  1. CALML4 in dopamine neurons, braakn/a → n/areceipt 12152
  2. CALML4 in microglia, braakn/a → n/areceipt 12151

Swarm cases

receipt 12152: CALML4 in dopamine neurons, braak

cell type
CALML4 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CALML4 in dopamine neurons.

case closed: nothing better to follow up.

receipt 12151: CALML4 in microglia, braak

cell type
CALML4 is not measured in microglia; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CALML4 in microglia.

case closed: nothing better to follow up.

Receipts

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