Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (renal collecting duct intercalated cells) | 0.10 |
| chemistry Open Targets | a small-molecule pocket: eptinezumab, galcanezumab, fremanezumab | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 293 | 0.82 |
| pathways Reactome | 3 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3845
Sealed predictions
- CALCA in dopamine neurons, braak-0.34 (p 0.378) → +0.57 (p 0.108)receipt 3852
Swarm cases
receipt 3852: CALCA in dopamine neurons, braak
- power
- full sample +0.01 (p 0.962, n 18), 95% CI -0.46 to +0.48. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.16 (p 0.515, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.14 (p 0.585, n 18). could be the mix.
- skeptic
- leave-one-out range -0.13 to +0.09, sign flips 6; without severely affected donors +0.01 (p 0.962, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CALCA in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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