Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.58 (overall 0.36) | 0.58 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 0862
Sealed predictions
- C2CD4A in dopamine neurons, braak-0.33 (p 0.383) → +0.42 (p 0.266)receipt 0868
Swarm cases
receipt 0868: C2CD4A in dopamine neurons, braak
- power
- full sample +0.10 (p 0.690, n 18), 95% CI -0.38 to +0.54. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.18 (p 0.476, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.17 (p 0.509, n 18). could be the mix.
- skeptic
- leave-one-out range -0.03 to +0.21, sign flips 2; without severely affected donors +0.10 (p 0.690, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for C2CD4A in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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