Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain inhibitory neurons; strongest in hofbauer cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 13 Parkinson's trials, 1 stopped | 0.94 |
| literature PubMed | 131 Parkinson's papers of 65,567 | 0.36 |
| pathways Reactome | 3 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 12669
Sealed predictions
- C2 in dopamine neurons, braak+0.11 (p 0.787) → -0.51 (p 0.161)receipt 12676
Swarm cases
receipt 12676: C2 in dopamine neurons, braak
- power
- full sample -0.12 (p 0.646, n 18), 95% CI -0.55 to +0.37. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.13 (p 0.609, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.16 (p 0.515, n 18). could be the mix.
- skeptic
- leave-one-out range -0.21 to +0.01, sign flips 1; without severely affected donors -0.12 (p 0.646, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for C2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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