Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (neutrophil progenitors) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 28 Parkinson's trials, 3 stopped | 0.91 |
| literature PubMed | 25 Parkinson's papers of 4,091 | 0.57 |
| pathways Reactome | 3 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 14622
Sealed predictions
- BPI in dopamine neurons, braak-0.20 (p 0.602) → -0.21 (p 0.586)receipt 14629
Swarm cases
receipt 14629: BPI in dopamine neurons, braak
- power
- full sample -0.23 (p 0.365, n 18), 95% CI -0.63 to +0.27. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.22 (p 0.379, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.46 (p 0.054, n 18). could be the mix.
- skeptic
- leave-one-out range -0.36 to -0.14, sign flips 0; without severely affected donors -0.23 (p 0.365, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for BPI in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts