Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in ependymal cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 18 | 0.91 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 3830
Sealed predictions
- BORCS7 in dopamine neurons, braak+0.77 (p 0.015) → +0.32 (p 0.407)receipt 3838
- BORCS7 in oligodendrocytes, braak+0.50 (p 0.168) → +0.08 (p 0.838)receipt 3837
Swarm cases
receipt 3838: BORCS7 in dopamine neurons, braak
- power
- full sample +0.56 (p 0.015, n 18), 95% CI +0.13 to +0.82. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.57 (p 0.013, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.58 (p 0.011, n 18). not the mix.
- skeptic
- leave-one-out range +0.51 to +0.70, sign flips 0; without severely affected donors +0.56 (p 0.015, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for BORCS7 in dopamine neurons.
case closed: nothing better to follow up.
receipt 3837: BORCS7 in oligodendrocytes, braak
- power
- full sample +0.31 (p 0.214, n 18), 95% CI -0.19 to +0.68. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.33 (p 0.182, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.28 (p 0.269, n 18). could be the mix.
- skeptic
- leave-one-out range +0.21 to +0.50, sign flips 0; without severely affected donors +0.31 (p 0.214, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for BORCS7 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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