parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	genetic association 0.10 (overall 0.06)	0.10
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in mesothelial cells	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 4385

receipt 4393: BNC2 in dopamine neurons, braak

power: full sample +0.22 (p 0.374, n 18), 95% CI -0.27 to +0.62. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.19 (p 0.460, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.15 (p 0.555, n 18). could be the mix.
skeptic: leave-one-out range +0.11 to +0.37, sign flips 0; without severely affected donors +0.22 (p 0.374, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for BNC2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 4392: BNC2 in microglia, braak

power: full sample -0.13 (p 0.621, n 18), 95% CI -0.56 to +0.36. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.13 (p 0.603, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.08 (p 0.767, n 18). could be the mix.
skeptic: leave-one-out range -0.25 to -0.00, sign flips 0; without severely affected donors -0.13 (p 0.621, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for BNC2 in microglia.

case closed: nothing better to follow up.

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