Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (tuft cells) | 0.10 |
| chemistry Open Targets | compounds already reach it: ritlecitinib tosylate, ritlecitinib | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 467 | 0.85 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 7777
Sealed predictions
- BMX in dopamine neurons, braak-0.36 (p 0.336) → +0.41 (p 0.273)receipt 7784
Swarm cases
receipt 7784: BMX in dopamine neurons, braak
- power
- full sample +0.10 (p 0.683, n 18), 95% CI -0.38 to +0.54. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.09 (p 0.722, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.24 (p 0.346, n 18). could be the mix.
- skeptic
- leave-one-out range -0.03 to +0.26, sign flips 3; without severely affected donors +0.10 (p 0.683, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for BMX in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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