Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

BMAL1

basic helix-loop-helix ARNT like 1

translation score 0.33, read 2026-10-19; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.09 from other evidence0.00
cell type
Human Protein Atlas
expressed broadly, no clear home in brain cells0.40
chemistry
Open Targets
a small-molecule pocket0.60
trials
ClinicalTrials.gov
1 Parkinson's trial, 1 stopped0.20
literature
PubMed
45 Parkinson's papers of 3,8030.50
pathways
Reactome
9 pathways; mostly growth signalling0.60

No case: the score is under the bar. Receipt 2845

Sealed predictions

  1. BMAL1 in dopamine neurons, braakn/a → n/areceipt 2852

Swarm cases

receipt 2852: BMAL1 in dopamine neurons, braak

cell type
BMAL1 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for BMAL1 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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