parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.45 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in microglia (5 nCPM)	1.00
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 0417

BLOC1S5 in dopamine neurons, braak-0.39 (p 0.306) → -0.22 (p 0.565)receipt 0425
BLOC1S5 in microglia, braak+0.25 (p 0.520) → +0.21 (p 0.581)receipt 0424

receipt 0425: BLOC1S5 in dopamine neurons, braak

power: full sample -0.22 (p 0.374, n 18), 95% CI -0.62 to +0.27. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.20 (p 0.434, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.21 (p 0.408, n 18). could be the mix.
skeptic: leave-one-out range -0.38 to -0.12, sign flips 0; without severely affected donors -0.22 (p 0.374, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for BLOC1S5 in dopamine neurons.

case closed: nothing better to follow up.

receipt 0424: BLOC1S5 in microglia, braak

power: full sample +0.04 (p 0.861, n 18), 95% CI -0.43 to +0.50. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.06 (p 0.814, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.06 (p 0.814, n 18). could be the mix.
skeptic: leave-one-out range -0.05 to +0.18, sign flips 6; without severely affected donors +0.04 (p 0.861, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for BLOC1S5 in microglia.

case closed: nothing better to follow up.

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