Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

BLOC1S4

biogenesis of lysosomal organelles complex 1 subunit 4

translation score 0.49, read 2026-10-27; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.01 from other evidence0.00
cell type
Human Protein Atlas
expressed broadly, no clear home in brain cells0.40
chemistry
Open Targets
hard to drug0.00
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
no papers tie it to Parkinson's yet1.00
pathways
Reactome
1 pathway; mostly vesicle traffic1.00

No case: the score is under the bar. Receipt 11851

Sealed predictions

  1. BLOC1S4 in dopamine neurons, braakn/a → n/areceipt 11858

Swarm cases

receipt 11858: BLOC1S4 in dopamine neurons, braak

cell type
BLOC1S4 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for BLOC1S4 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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