Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in thymic myoid cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 27 Parkinson's papers of 758 | 0.56 |
| pathways Reactome | 1 pathway; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 6343
Sealed predictions
- BIN1 in oligodendrocytes, braak-0.03 (p 0.944) → -0.29 (p 0.456)receipt 6350
- BIN1 in dopamine neurons, braak-0.15 (p 0.705) → -0.75 (p 0.020)receipt 6351
Swarm cases
receipt 6351: BIN1 in dopamine neurons, braak
- power
- full sample -0.40 (p 0.103, n 18), 95% CI -0.73 to +0.09. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.46 (p 0.055, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.46 (p 0.057, n 18). could be the mix.
- skeptic
- leave-one-out range -0.54 to -0.31, sign flips 0; without severely affected donors -0.40 (p 0.103, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for BIN1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 6350: BIN1 in oligodendrocytes, braak
- power
- full sample -0.23 (p 0.355, n 18), 95% CI -0.63 to +0.26. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.21 (p 0.398, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.22 (p 0.374, n 18). could be the mix.
- skeptic
- leave-one-out range -0.42 to -0.13, sign flips 0; without severely affected donors -0.23 (p 0.355, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for BIN1 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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