Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

BGLAP

bone gamma-carboxyglutamate protein

translation score 0.61, read 2026-10-19; 2 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.08 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including oligodendrocytes; strongest in plasma cells0.75
chemistry
Open Targets		a small-molecule pocket0.60
trials
ClinicalTrials.gov		1 Parkinson's trial, 0 stopped1.00
literature
PubMed		no papers tie it to Parkinson's yet1.00
pathways
Reactome		4 pathways; mostly vesicle traffic1.00
proposal for BGLAP, translation score 0.61

Knock down and overexpress BGLAP in oligodendrocytes; measure LRRK2 kinase activity (pT73-Rab10) and lysosome position and α-synuclein uptake and myelin basic protein output under oxidative stress.

Cell type
oligodendrocytes
Direction
Both arms: public data does not say which way helps.
Molecular readout
LRRK2 kinase activity (pT73-Rab10) and lysosome position
Functional readout
α-synuclein uptake and myelin basic protein output under oxidative stress
Rule-out
If neither arm moves LRRK2 kinase activity (pT73-Rab10) by 20% or more against non-targeting and empty-vector controls, across three independent differentiations, the hypothesis is wrong.
Lab request
CRISPRi knockdown and lentiviral overexpression of BGLAP in iPSC-derived oligodendrocytes; n = 3 differentiations; readouts: LRRK2 kinase activity (pT73-Rab10) and lysosome position; α-synuclein uptake and myelin basic protein output under oxidative stress. Controls: non-targeting guide, empty vector. About 8 to 10 weeks, most of it differentiation.

Sealed predictions

  1. BGLAP in dopamine neurons, braakn/a → n/areceipt 3274
  2. BGLAP in oligodendrocytes, braakn/a → n/areceipt 3273

Swarm cases

receipt 3274: BGLAP in dopamine neurons, braak

cell type
BGLAP is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for BGLAP in dopamine neurons.

case closed: nothing better to follow up.

receipt 3273: BGLAP in oligodendrocytes, braak

cell type
BGLAP is not measured in oligodendrocytes; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for BGLAP in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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