Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (platelets) | 0.10 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 69 | 0.91 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 10948
Sealed predictions
- BEND2 in dopamine neurons, braak+0.42 (p 0.258) → +0.35 (p 0.361)receipt 10955
Swarm cases
receipt 10955: BEND2 in dopamine neurons, braak
- power
- full sample +0.37 (p 0.135, n 18), 95% CI -0.12 to +0.71. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.58 (p 0.011, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.54 (p 0.022, n 18). not the mix.
- skeptic
- leave-one-out range +0.27 to +0.45, sign flips 0; without severely affected donors +0.37 (p 0.135, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for BEND2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts