Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in retinal horizontal cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.40 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 9336
Sealed predictions
- B3GAT2 in dopamine neurons, braak+0.19 (p 0.618) → +0.86 (p 0.003)receipt 9343
- B3GAT2 in oligodendrocytes, braak-0.16 (p 0.672) → +0.26 (p 0.502)receipt 9342
Swarm cases
receipt 9343: B3GAT2 in dopamine neurons, braak
- power
- full sample +0.53 (p 0.023, n 18), 95% CI +0.09 to +0.80. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.52 (p 0.027, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.52 (p 0.027, n 18). not the mix.
- skeptic
- leave-one-out range +0.47 to +0.73, sign flips 0; without severely affected donors +0.53 (p 0.023, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for B3GAT2 in dopamine neurons.
case closed: nothing better to follow up.
receipt 9342: B3GAT2 in oligodendrocytes, braak
- power
- full sample -0.07 (p 0.794, n 18), 95% CI -0.52 to +0.41. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.02 (p 0.942, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.10 (p 0.696, n 18). could be the mix.
- skeptic
- leave-one-out range -0.17 to +0.07, sign flips 4; without severely affected donors -0.07 (p 0.794, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for B3GAT2 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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