Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.05 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in epicardial cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 21 | 0.91 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 5307
Sealed predictions
- B3GALT2 in dopamine neurons, braak+0.11 (p 0.773) → +0.03 (p 0.944)receipt 5316
- B3GALT2 in oligodendrocytes, braak+0.26 (p 0.493) → -0.17 (p 0.668)receipt 5315
Swarm cases
receipt 5316: B3GALT2 in dopamine neurons, braak
- power
- full sample +0.14 (p 0.591, n 18), 95% CI -0.35 to +0.57. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.06 (p 0.800, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.07 (p 0.794, n 18). could be the mix.
- skeptic
- leave-one-out range +0.03 to +0.27, sign flips 0; without severely affected donors +0.14 (p 0.591, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for B3GALT2 in dopamine neurons.
case closed: nothing better to follow up.
receipt 5315: B3GALT2 in oligodendrocytes, braak
- power
- full sample +0.06 (p 0.820, n 18), 95% CI -0.42 to +0.51. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.02 (p 0.949, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.08 (p 0.767, n 18). could be the mix.
- skeptic
- leave-one-out range -0.01 to +0.22, sign flips 3; without severely affected donors +0.06 (p 0.820, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for B3GALT2 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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