Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (corticotrophs) | 0.10 |
| chemistry Open Targets | compounds already reach it: desmopressin acetate, nelivaptan, lypressin +4 | 0.90 |
| trials ClinicalTrials.gov | 2 Parkinson's trials, 2 stopped | 0.20 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 3 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 13897
Sealed predictions
- AVPR1B in dopamine neurons, braak+0.12 (p 0.767) → -0.80 (p 0.010)receipt 13905
Swarm cases
receipt 13905: AVPR1B in dopamine neurons, braak
- power
- full sample -0.23 (p 0.355, n 18), 95% CI -0.63 to +0.26. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.23 (p 0.355, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.43 (p 0.074, n 18). could be the mix.
- skeptic
- leave-one-out range -0.36 to -0.14, sign flips 0; without severely affected donors -0.23 (p 0.355, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for AVPR1B in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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