Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.09 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in retinal pigment epithelial cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 14 Parkinson's papers of 27 | 0.64 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2820
Sealed predictions
- ATP10B in dopamine neurons, braak+0.49 (p 0.177) → +0.20 (p 0.613)receipt 2828
- ATP10B in oligodendrocytes, braak-0.06 (p 0.877) → -0.29 (p 0.457)receipt 2827
Swarm cases
receipt 2828: ATP10B in dopamine neurons, braak
- power
- full sample +0.19 (p 0.450, n 18), 95% CI -0.30 to +0.60. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.27 (p 0.281, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.25 (p 0.323, n 18). could be the mix.
- skeptic
- leave-one-out range +0.09 to +0.28, sign flips 0; without severely affected donors +0.19 (p 0.450, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ATP10B in dopamine neurons.
case closed: nothing better to follow up.
receipt 2827: ATP10B in oligodendrocytes, braak
- power
- full sample -0.14 (p 0.573, n 18), 95% CI -0.57 to +0.35. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.07 (p 0.794, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.06 (p 0.814, n 18). could be the mix.
- skeptic
- leave-one-out range -0.27 to -0.02, sign flips 0; without severely affected donors -0.14 (p 0.573, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ATP10B in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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