Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (platelets) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 104 | 0.91 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 10344
Sealed predictions
- AQP10 in dopamine neurons, braak+0.07 (p 0.856) → -0.12 (p 0.749)receipt 10351
Swarm cases
receipt 10351: AQP10 in dopamine neurons, braak
- power
- full sample -0.03 (p 0.901, n 18), 95% CI -0.49 to +0.44. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.02 (p 0.949, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.03 (p 0.915, n 18). could be the mix.
- skeptic
- leave-one-out range -0.15 to +0.10, sign flips 5; without severely affected donors -0.03 (p 0.901, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for AQP10 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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