Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

APOC2

apolipoprotein C2

translation score 0.59, read 2026-10-19; 2 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets		genetic association 0.14 (overall 0.09)0.14
cell type
Human Protein Atlas		cell type enriched in microglia (296 nCPM)1.00
chemistry
Open Targets		reachable by antibody0.45
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		3 Parkinson's papers of 4290.82
pathways
Reactome		6 pathways; mostly energy0.60
proposal for APOC2, translation score 0.59

Knock down and overexpress APOC2 in microglia; measure oxygen consumption rate and ATP output and uptake and clearance of α-synuclein fibrils and NLRP3 inflammasome activation (IL-1β release).

Cell type
microglia
Direction
Both arms: public data does not say which way helps.
Molecular readout
oxygen consumption rate and ATP output
Functional readout
uptake and clearance of α-synuclein fibrils and NLRP3 inflammasome activation (IL-1β release)
Rule-out
If neither arm moves oxygen consumption rate by 20% or more against non-targeting and empty-vector controls, across three independent differentiations, the hypothesis is wrong.
Lab request
CRISPRi knockdown and lentiviral overexpression of APOC2 in iPSC-derived microglia (iMGL); n = 3 differentiations; readouts: oxygen consumption rate and ATP output; uptake and clearance of α-synuclein fibrils and NLRP3 inflammasome activation (IL-1β release). Controls: non-targeting guide, empty vector. About 8 to 10 weeks, most of it differentiation.

Sealed predictions

  1. APOC2 in microglia, braakn/a → n/areceipt 2940
  2. APOC2 in dopamine neurons, braakn/a → n/areceipt 2941

Swarm cases

receipt 2941: APOC2 in dopamine neurons, braak

cell type
APOC2 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for APOC2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 2940: APOC2 in microglia, braak

cell type
APOC2 is not measured in microglia; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for APOC2 in microglia.

case closed: nothing better to follow up.

Receipts

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