Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (hepatocytes) | 0.10 |
| chemistry Open Targets | reachable by antibody: mipomersen sodium, mipomersen | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 20 Parkinson's papers of 11,475 | 0.60 |
| pathways Reactome | 20 pathways; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 3345
Sealed predictions
- APOB in dopamine neurons, braak+0.35 (p 0.361) → +0.61 (p 0.078)receipt 3351
Swarm cases
receipt 3351: APOB in dopamine neurons, braak
- power
- full sample +0.54 (p 0.021, n 18), 95% CI +0.10 to +0.80. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.56 (p 0.015, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.54 (p 0.021, n 18). not the mix.
- skeptic
- leave-one-out range +0.47 to +0.62, sign flips 0; without severely affected donors +0.54 (p 0.021, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for APOB in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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