parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.03 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in adrenal medulla cells	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	2 Parkinson's papers of 248	0.85
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 6461

receipt 6469: APLN in dopamine neurons, braak

power: full sample -0.26 (p 0.294, n 18), 95% CI -0.65 to +0.23. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.38 (p 0.118, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.36 (p 0.140, n 18). could be the mix.
skeptic: leave-one-out range -0.40 to -0.17, sign flips 0; without severely affected donors -0.26 (p 0.294, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for APLN in dopamine neurons.

case closed: nothing better to follow up.

receipt 6468: APLN in astrocytes, braak

power: full sample -0.10 (p 0.696, n 18), 95% CI -0.54 to +0.39. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.07 (p 0.781, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.03 (p 0.894, n 18). could be the mix.
skeptic: leave-one-out range -0.20 to +0.02, sign flips 2; without severely affected donors -0.10 (p 0.696, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for APLN in astrocytes.

case closed: nothing better to follow up.

loading the receipts