Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.08 (overall 0.05) | 0.08 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 5290
Sealed predictions
- AMPD3 in dopamine neurons, braak-0.26 (p 0.493) → -0.19 (p 0.618)receipt 5297
Swarm cases
receipt 5297: AMPD3 in dopamine neurons, braak
- power
- full sample -0.33 (p 0.176, n 18), 95% CI -0.69 to +0.16. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.41 (p 0.091, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.40 (p 0.099, n 18). could be the mix.
- skeptic
- leave-one-out range -0.49 to -0.25, sign flips 0; without severely affected donors -0.33 (p 0.176, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for AMPD3 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts