Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.32 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in hepatocytes | 0.75 |
| chemistry Open Targets | hard to drug | 0.40 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 1146
Sealed predictions
- ALDH8A1 in oligodendrocytes, braak+0.00 (p 1.000) → -0.53 (p 0.145)receipt 1151
- ALDH8A1 in dopamine neurons, braak-0.46 (p 0.217) → +0.03 (p 0.944)receipt 1152
Swarm cases
receipt 1152: ALDH8A1 in dopamine neurons, braak
- power
- full sample -0.36 (p 0.137, n 18), 95% CI -0.71 to +0.12. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.36 (p 0.148, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.38 (p 0.123, n 18). could be the mix.
- skeptic
- leave-one-out range -0.43 to -0.29, sign flips 0; without severely affected donors -0.36 (p 0.137, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ALDH8A1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 1151: ALDH8A1 in oligodendrocytes, braak
- power
- full sample -0.42 (p 0.082, n 18), 95% CI -0.74 to +0.06. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.41 (p 0.091, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.34 (p 0.167, n 18). could be the mix.
- skeptic
- leave-one-out range -0.48 to -0.32, sign flips 0; without severely affected donors -0.42 (p 0.082, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ALDH8A1 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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