parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in hepatocytes	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	3 Parkinson's papers of 296	0.82
pathways Reactome	1 pathway; mostly energy	0.60

No case: the score is under the bar. Receipt 9225

ALDH1L1 in dopamine neurons, braak-0.38 (p 0.316) → -0.55 (p 0.128)receipt 9232
ALDH1L1 in astrocytes, braak+0.52 (p 0.153) → +0.11 (p 0.787)receipt 9231

receipt 9232: ALDH1L1 in dopamine neurons, braak

power: full sample -0.39 (p 0.111, n 18), 95% CI -0.72 to +0.10. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.34 (p 0.173, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.51 (p 0.031, n 18). not the mix.
skeptic: leave-one-out range -0.52 to -0.31, sign flips 0; without severely affected donors -0.39 (p 0.111, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ALDH1L1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 9231: ALDH1L1 in astrocytes, braak

power: full sample +0.21 (p 0.413, n 18), 95% CI -0.29 to +0.61. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.21 (p 0.413, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.21 (p 0.413, n 18). could be the mix.
skeptic: leave-one-out range +0.10 to +0.35, sign flips 0; without severely affected donors +0.21 (p 0.413, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ALDH1L1 in astrocytes.

case closed: nothing better to follow up.

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