Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.11 from other evidence | 0.00 |
| cell type Human Protein Atlas | enriched in the midbrain (739 nTPM), where the nigral dopamine neurons sit | 0.90 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 71 Parkinson's papers of 1,453 | 0.44 |
| pathways Reactome | 6 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2518
Sealed predictions
- ALDH1A1 in dopamine neurons, braak-0.03 (p 0.929) → +0.45 (p 0.219)receipt 2526
In the sealed studies
Swarm cases
receipt 2526: ALDH1A1 in dopamine neurons, braak
- power
- full sample +0.22 (p 0.379, n 18), 95% CI -0.27 to +0.62. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.18 (p 0.476, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.24 (p 0.341, n 18). could be the mix.
- skeptic
- leave-one-out range +0.11 to +0.37, sign flips 0; without severely affected donors +0.22 (p 0.379, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ALDH1A1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts