Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.11 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (hepatocytes) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 176 Parkinson's trials, 4 stopped | 0.94 |
| literature PubMed | 28 Parkinson's papers of 9,844 | 0.56 |
| pathways Reactome | 12 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 2491
Sealed predictions
- ALB in dopamine neurons, braak+0.61 (p 0.078) → +0.25 (p 0.524)receipt 2498
Swarm cases
receipt 2498: ALB in dopamine neurons, braak
- power
- full sample +0.47 (p 0.047, n 18), 95% CI +0.01 to +0.77. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.42 (p 0.084, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.47 (p 0.051, n 18). could be the mix.
- skeptic
- leave-one-out range +0.40 to +0.56, sign flips 0; without severely affected donors +0.47 (p 0.047, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ALB in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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