Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in neutrophils | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 53 | 0.91 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3546
Sealed predictions
- AGTPBP1 in dopamine neurons, braak+0.58 (p 0.104) → +0.18 (p 0.638)receipt 3555
- AGTPBP1 in oligodendrocytes, braak-0.06 (p 0.870) → +0.00 (p 1.000)receipt 3554
Swarm cases
receipt 3555: AGTPBP1 in dopamine neurons, braak
- power
- full sample +0.22 (p 0.374, n 18), 95% CI -0.27 to +0.62. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.23 (p 0.365, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.29 (p 0.246, n 18). could be the mix.
- skeptic
- leave-one-out range +0.12 to +0.35, sign flips 0; without severely affected donors +0.22 (p 0.374, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for AGTPBP1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 3554: AGTPBP1 in oligodendrocytes, braak
- power
- full sample +0.11 (p 0.652, n 18), 95% CI -0.37 to +0.55. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.10 (p 0.683, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.09 (p 0.709, n 18). could be the mix.
- skeptic
- leave-one-out range +0.03 to +0.28, sign flips 0; without severely affected donors +0.11 (p 0.652, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for AGTPBP1 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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