parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.03 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including oligodendrocyte progenitor cells; strongest in cone photoreceptor cells	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	2 Parkinson's papers of 53	0.85
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 7139

receipt 7147: AGAP1 in dopamine neurons, braak

power: full sample -0.44 (p 0.069, n 18), 95% CI -0.75 to +0.04. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.40 (p 0.097, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.43 (p 0.075, n 18). could be the mix.
skeptic: leave-one-out range -0.57 to -0.36, sign flips 0; without severely affected donors -0.44 (p 0.069, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for AGAP1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 7146: AGAP1 in oligodendrocytes, braak

power: full sample -0.19 (p 0.460, n 18), 95% CI -0.60 to +0.31. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.05 (p 0.840, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.05 (p 0.854, n 18). could be the mix.
skeptic: leave-one-out range -0.36 to -0.11, sign flips 0; without severely affected donors -0.19 (p 0.460, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for AGAP1 in oligodendrocytes.

case closed: nothing better to follow up.

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