Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

AFF1

ALF transcription elongation factor 1

translation score 0.34, read 2026-10-21; 1 sealed predictions, 1 held; 1 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.05 from other evidence0.00
cell type
Human Protein Atlas
expressed broadly, no clear home in brain cells0.40
chemistry
Open Targets
hard to drug0.00
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
1 Parkinson's papers of 2270.91
pathways
Reactome
in no curated pathway0.00

No case: the score is under the bar. Receipt 4811

Sealed predictions

  1. AFF1 in dopamine neurons, braak-0.75 (p 0.021) → -0.70 (p 0.037)held

Swarm cases

No cases yet. The swarm opens one after the first failed atlas prediction.

Receipts

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