Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

ADRA2C

adrenoceptor alpha 2C

translation score 0.46, read 2026-10-17; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.37 from other evidence0.00
cell type
Human Protein Atlas
cell type enhanced outside the brain (endometrial stromal cells)0.10
chemistry
Open Targets
compounds already reach it: apraclonidine, dipivefrin, ephedrine hydrochloride +551.00
trials
ClinicalTrials.gov
3 Parkinson's trials, 1 stopped0.73
literature
PubMed
2 Parkinson's papers of 1000.85
pathways
Reactome
6 pathways; mostly energy0.60

No case: the score is under the bar. Receipt 0810

Sealed predictions

  1. ADRA2C in dopamine neurons, braakn/a → n/areceipt 0819

Swarm cases

receipt 0819: ADRA2C in dopamine neurons, braak

cell type
ADRA2C is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ADRA2C in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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