Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.37 (overall 0.23) | 0.37 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (conjunctival goblet cells) | 0.10 |
| chemistry Open Targets | compounds already reach it: fomepizole, nitrefazole | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 6 Parkinson's papers of 347 | 0.74 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 1845
Sealed predictions
- ADH1C in dopamine neurons, braak+0.22 (p 0.569) → +0.43 (p 0.251)receipt 1852
Swarm cases
receipt 1852: ADH1C in dopamine neurons, braak
- power
- full sample +0.21 (p 0.398, n 18), 95% CI -0.28 to +0.62. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.21 (p 0.398, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.18 (p 0.471, n 18). could be the mix.
- skeptic
- leave-one-out range +0.12 to +0.40, sign flips 0; without severely affected donors +0.21 (p 0.398, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ADH1C in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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