Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.10 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain inhibitory neurons; strongest in retinal ganglion cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2760
Sealed predictions
- ADAM23 in dopamine neurons, braak+0.36 (p 0.347) → +0.46 (p 0.214)receipt 2766
Swarm cases
receipt 2766: ADAM23 in dopamine neurons, braak
- power
- full sample +0.44 (p 0.070, n 18), 95% CI -0.04 to +0.75. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.41 (p 0.087, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.44 (p 0.067, n 18). could be the mix.
- skeptic
- leave-one-out range +0.37 to +0.59, sign flips 0; without severely affected donors +0.44 (p 0.070, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ADAM23 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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