parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in syncytiotrophoblasts	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 14070

ACSS1 in dopamine neurons, braak-0.61 (p 0.084) → -0.39 (p 0.306)receipt 14078
ACSS1 in astrocytes, braak-0.72 (p 0.029) → +0.45 (p 0.227)receipt 14077

receipt 14078: ACSS1 in dopamine neurons, braak

power: full sample -0.43 (p 0.077, n 18), 95% CI -0.75 to +0.05. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.42 (p 0.082, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.48 (p 0.044, n 18). not the mix.
skeptic: leave-one-out range -0.53 to -0.36, sign flips 0; without severely affected donors -0.43 (p 0.077, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ACSS1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 14077: ACSS1 in astrocytes, braak

power: full sample +0.03 (p 0.915, n 18), 95% CI -0.45 to +0.49. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.02 (p 0.949, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.16 (p 0.538, n 18). could be the mix.
skeptic: leave-one-out range -0.11 to +0.15, sign flips 5; without severely affected donors +0.03 (p 0.915, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ACSS1 in astrocytes.

case closed: nothing better to follow up.

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