Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.24 (overall 0.15) | 0.24 |
| cell type Human Protein Atlas | cell type enriched outside the brain (extravillous trophoblasts) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 1,492 | 0.91 |
| pathways Reactome | 7 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 2191
Sealed predictions
- ACAN in dopamine neurons, braak-0.32 (p 0.407) → -0.21 (p 0.586)receipt 2198
Swarm cases
receipt 2198: ACAN in dopamine neurons, braak
- power
- full sample -0.26 (p 0.306, n 18), 95% CI -0.65 to +0.24. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.39 (p 0.111, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.54 (p 0.021, n 18). not the mix.
- skeptic
- leave-one-out range -0.40 to -0.16, sign flips 0; without severely affected donors -0.26 (p 0.306, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ACAN in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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