parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.36 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including oligodendrocytes; strongest in proximal tubule cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	3 Parkinson's papers of 165	0.82
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 0853

receipt 0861: ABHD6 in dopamine neurons, braak

power: full sample -0.07 (p 0.794, n 18), 95% CI -0.52 to +0.41. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.06 (p 0.814, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.06 (p 0.807, n 18). could be the mix.
skeptic: leave-one-out range -0.15 to +0.08, sign flips 4; without severely affected donors -0.07 (p 0.794, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ABHD6 in dopamine neurons.

case closed: nothing better to follow up.

receipt 0860: ABHD6 in oligodendrocytes, braak

power: full sample +0.10 (p 0.690, n 18), 95% CI -0.38 to +0.54. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.11 (p 0.664, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.18 (p 0.487, n 18). could be the mix.
skeptic: leave-one-out range -0.03 to +0.25, sign flips 2; without severely affected donors +0.10 (p 0.690, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ABHD6 in oligodendrocytes.

case closed: nothing better to follow up.

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