Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.10 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: zosuquidar, tariquidar, valspodar +2 | 0.90 |
| trials ClinicalTrials.gov | 3 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 38 Parkinson's papers of 6,806 | 0.52 |
| pathways Reactome | 4 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2541
Sealed predictions
- ABCB1 in dopamine neurons, braak-0.15 (p 0.701) → +0.43 (p 0.243)receipt 2548
Swarm cases
receipt 2548: ABCB1 in dopamine neurons, braak
- power
- full sample +0.01 (p 0.983, n 18), 95% CI -0.46 to +0.47. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.02 (p 0.949, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.02 (p 0.942, n 18). could be the mix.
- skeptic
- leave-one-out range -0.15 to +0.11, sign flips 6; without severely affected donors +0.01 (p 0.983, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ABCB1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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