Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

AARS1

alanyl-tRNA synthetase 1

translation score 0.44, read 2026-10-20; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.07 from other evidence0.00
cell type
Human Protein Atlas
expressed broadly, no clear home in brain cells0.40
chemistry
Open Targets
a small-molecule pocket0.60
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
2 Parkinson's papers of 1040.85
pathways
Reactome
1 pathway; mostly other0.30

No case: the score is under the bar. Receipt 3839

Sealed predictions

  1. AARS1 in dopamine neurons, braakn/a → n/areceipt 3846

Swarm cases

receipt 3846: AARS1 in dopamine neurons, braak

cell type
AARS1 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for AARS1 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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