Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in oligodendrocytes (23 nCPM) | 1.00 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 10483
Sealed predictions
- A1BG in dopamine neurons, braak+0.04 (p 0.927) → +0.08 (p 0.833)receipt 10490
- A1BG in oligodendrocytes, braakn/a → n/areceipt 10489
Swarm cases
receipt 10490: A1BG in dopamine neurons, braak
- power
- full sample +0.04 (p 0.867, n 18), 95% CI -0.43 to +0.50. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.08 (p 0.741, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.01 (p 0.983, n 18). could be the mix.
- skeptic
- leave-one-out range -0.07 to +0.17, sign flips 5; without severely affected donors +0.04 (p 0.867, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for A1BG in dopamine neurons.
case closed: nothing better to follow up.
receipt 10489: A1BG in oligodendrocytes, braak
- cell type
- A1BG is not measured in oligodendrocytes; looking elsewhere.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for A1BG in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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